Daniel A. Lorenz

Post-Doctoral Fellow Alumni
Cellular and Molecular Medicine
d2lorenz at ucsd.edu

Degrees

B.S. Biochemistry with minor in Biology, Sonoma State University, 2013
Ph.D. Chemical Biology, University of Michigan, 2018

Summary

Daniel received his B.S. in Biochemistry from Sonoma State University in 2013. While at the college, he worked in Dr. Jon Fukuto’s laboratory to understand the mechanism of hydrogen sulfide signaling. Daniel also spent time working in Dr. Brian Kennedy’s lab at the Buck Institute for Research on Aging. There, he studied membrane fluidity and chemotaxis in both yeast and C. elegans. After graduating, Daniel joined Dr. Amanda Garner’s Lab at the University of Michigan and obtained his Ph.D. in Chemical Biology in 2018. His thesis research focused on developing new technologies to facilitate the targeting of RNA and RNA binding proteins with small molecules. With these new assays, Daniel conducted two high-throughput screening campaigns, totaling over 200,000 compounds, that resulted in the discovery of several unique scaffolds. Now a member of the Yeo lab, Daniel is interested in uncovering the biological functions of various RNA modifications and understanding RNA localization.

Publications

  • Lorenz D. A.§, Sathe S§, Einstein J. M., Yeo G. W. Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base specific resolution. RNA. 2019

  • Lorenz, D. A.; Kerk, S.; Cohen, S. M.; Garner, A. L. A Click Chemistry Based RNA-Protein Interaction Assay for Probe Discovery, ACS Med. Chem. Lett. 2018

  • Lorenz, D. A.; Vander Roest, S.; Larsen, M. J., Garner, A. L. Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small Molecule Ligands for pre-microRNAs, SLAS Discovery 2018

  • Lorenz, D. A.; Garner, A. L. A Click Chemistry-Based microRNA Maturation Assay Optimized for HighThroughput Screening Chem. Commun. 2016

  • Lorenz, D. A.; Song, J. M.; Garner, A. L. High-throughput platform assay technology for the discovery of pre-microRNA-selective small molecule probes Bioconjugate Chemistry 2015

  • Lockshon, D.; Olsen, C. P.; Brett, C. L.; Chertov, A.; Merz, A. J.; Lorenz, D. A.; Van Gilst, M. R.; Kennedy, B. K. Rho signaling participates in membrane fluidity homeostasis PLoS ONE 2012