Julia K. Nussbacher

Graduate Student Alumni
Cellular and Molecular Medicine
jnussbac at ucsd.edu

Degrees

Ph.D., Biomedical Sciences, University of California San Diego, 2017
Sc.B Biochemistry, Brown University, 2010

Summary

Julia comes to us with experience in both academia and industry, in fields ranging from cancer diagnostics to antibiotic synthesis. As an undergraduate at Brown University, Julia completed a thesis project in the lab of Dr. Anatoly Zhitkovich. She used a lung cancer model to study the role of mismatch repair proteins in the development of chemotherapeutic resistance to DNA crosslinking compounds. Prior to joining the graduate program in biomedical sciences, Julia worked in the biotech industry in drug development and diagnostics. As a graduate student in our lab Julia is interested in the epigenetics of the transcriptome. She hopes to apply her knowledge of biochemistry and developing computational skills to understanding how RNA modifications influence neural development and neurodegeneration. When not in the lab, Julia can usually be found lifting heavy things and eating donuts.

Publications

  • Nussbacher JK. Tabet R, Yeo GW, Lagier-Tourenne C. Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions. Neuron 2019.

  • Tan FE , Sathe S , Wheeler EC, Nussbacher JK, Peter S, Yeo GW. A Transcriptome-wide Translational Program Defined by LIN28B Expression Level. Molecular Cell 2019.

  • Nussbacher JK and Yeo GW. Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels. Molecular Cell 2018.

  • Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M, Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Science Signal 2017.

  • Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M Jr, Burge CB, Taylor JP, Rigo F, Yeo GW. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016.

  • Bos TJ, Nussbacher JK, Aigner S, Yeo GW, Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins. Advances in Experimental Medicine and Biology 2016.

  • Nussbacher JK, Batra R; Lagier-Tourenne C, Yeo GW, RNA-binding proteins in neurodegeneration: Seq and you shall receive. Trends in Neurosciences 2015.

  • Axelsson H, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, and Esko JD. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood 2012.