Yeo Lab

Degrees

Ph.D., Biology with Specialization in Bioinformatics, University of California, San Diego, 2009
M.Sc, Pharmacy and Molecular Biology, University of Sao Paulo, Brazil 2000
B.S., Pharmacy and Clinical Analysis, Federal University of Santa Maria, 1996

Summary

Katlin B. Massirer received her M.Sc. in Pharmacy and Molecular Biology from the University of Sao Paulo, Brazil in 2000 and her Ph.D from the University of California, San Diego in 2009, from Amy E. Pasquinelli’s laboratory. During her Masters Katlin studied interferon response in patients with hepatitis C. This work gave her experience with molecular biology and with clinical studies and the contact with patients. After her Masters, while preparing to do her Ph.D. abroad, Katlin worked on the Brazilian Cancer Genome Project as a lab technician and as a bioinformatics researcher. This was a multi-center project that resulted in large part of the cancer ESTs publicly available at the time. During her Ph.D in the Pasquinelli lab Katlin studied a cluster of embryonic miRNAs in C. elegans. She combined genetics, molecular biology, microscopy and computation to define a role for the mir-35-41 cluster in embryo development. Katlin also likes to teach science and is a volunteer for the Salk Mobile Lab and for the Annual San Diego Science and Engineering Fair. Now her research in the Yeo lab will focus on miRNA but more related to RNA binding protein biology applied to stem cell research.

Publications

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Wilbert MW, Huelga SC, Kapeli K, Stark TJ, Liang TY, Chen SX, Yan BY, Nathanson JL, Hutt KR, Lovci MT, Kazan H, Vu AQ, Massirer KB, Morris Q, Hoon S, Yeo GW. Molecular Cell, 2012. [Mol Cell][PDF]

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Van Wynsberghe PM, Kai ZS, Massirer KB, Burton VH, Yeo GW, Pasquinelli AE. Nature Structural and Molecular Biology, 2011. [PMID: 21297634]

Maintenance and differentiation of neural stem cells. Massirer KB, Carromeu C, Griesi-Oliveira K, Muotri AR. Wiley Interdiscip Rev Syst Biol Med, 2011. [PMID: 21061307]

Massirer K.B., Pasquinelli A.E. The evolving role of microRNAs in animal gene expression. Bioessays, 2006 May;28(5):449-52. Review. [PMID: 16615087]

Bagga, S., J. Bracht, S. Hunter, K. Massirer, J. Holtz, R. Eachus, and A.E. Pasquinelli. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell, 2005 Aug 26;122(4):553-63. [PMID: 16122423]

Fujita A., Massirer K.B., Durham A.M., Ferreira C.E., Sogayar M.C. The GATO gene annotation tool for research laboratories. Braz J Med Biol Res, 2005 Nov;38(11):1571-4. Epub 2005 Oct 26. [PMID: 16258624]

Reis, E.M., E.P. Ojopi, F.L. Alberto, P. Rahal, F. Tsukumo, U.M. Mancini, G.S. Guimaraes, G.M. Thompson, C. Camacho, E. Miracca, A.L. Carvalho, A.A. Machado, A.C. Paquola, J.M. Cerutti, A.M. da Silva, G.G. Pereira, S.R. Valentini, M.A. Nagai, L.P. Kowalski, S. Verjovski-Almeida, E.H. Tajara, E. Dias-Neto, M.H. Bengtson, R.A. Canevari, M.F. Carazzolle, C. Colin, F.F. Costa, M.C. Costa, M.R. Estecio, L.I. Esteves, M.H. Federico, P.E. Guimaraes, C. Hackel, E.T. Kimura, S.G. Leoni, R.M. Maciel, S. Maistro, F.R. Mangone, K.B. Massirer, S.E. Matsuo, F.G. Nobrega, M.P. Nobrega, D.N. Nunes, F. Nunes, J.R. Pandolfi, M.I. Pardini, F.S. Pasini, T. Peres, C.A. Rainho, P.P. dos Reis, F.C. Rodrigus-Lisoni, S.R. Rogatto, A. dos Santos, P.C. dos Santos, M.C. Sogayar, and C.F. Zanelli. Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer. Cancer Res, 2005 Mar 1;65(5):1693-9. [PMID: 15753364]

Sogayar, M.C., A.A. Camargo, F. Bettoni, D.M. Carraro, L.C. Pires, R.B. Parmigiani, E.N. Ferreira, E. de Sa Moreira, D.d.O.L.M. do Rosario, A.J. Simpson, L.O. Cruz, T.L. Degaki, F. Festa, K.B. Massirer, M.C. Sogayar, F.C. Filho, L.P. Camargo, M.A. Cunha, S.J. De Souza, M. Faria, Jr., S. Giuliatti, L. Kopp, P.S. de Oliveira, P.B. Paiva, A.A. Pereira, D.G. Pinheiro, R.D. Puga, S.d.S. JE, D.M. Albuquerque, L.E. Andrade, G.S. Baia, M.R. Briones, A.M. Cavaleiro-Luna, J.M. Cerutti, F.F. Costa, E. Costanzi-Strauss, E.M. Espreafico, A.C. Ferrasi, E.S. Ferro, M.A. Fortes, J.R. Furchi, D. Giannella-Neto, G.H. Goldman, M.H. Goldman, A. Gruber, G.S. Guimaraes, C. Hackel, F. Henrique-Silva, E.T. Kimura, S.G. Leoni, C. Macedo, B. Malnic, B.C. Manzini, S.K. Marie, N.M. Martinez-Rossi, M. Menossi, E.C. Miracca, M.A. Nagai, F.G. Nobrega, M.P. Nobrega, S.M. Oba-Shinjo, M.K. Oliveira, G.M. Orabona, A.Y. Otsuka, M.L. Paco-Larson, B.M. Paixao, J.R. Pandolfi, M.I. Pardini, M.R. Passos Bueno, G.A. Passos, J.B. Pesquero, J.G. Pessoa, P. Rahal, C.A. Rainho, C.P. Reis, T.I. Ricca, V. Rodrigues, S.R. Rogatto, C.M. Romano, J.G. Romeiro, A. Rossi, R.G. Sa, M.M. Sales, S.C. Sant’Anna, P.L. Santarosa, F. Segato, W.A. Silva, Jr., I.D. Silva, N.P. Silva, A. Soares-Costa, M.F. Sonati, B.E. Strauss, E.H. Tajara, S.R. Valentini, F.E. Villanova, L.S. Ward, and D.L. Zanette. A transcript finishing initiative for closing gaps in the human transcriptome. Genome Res, 2004 Jul;14(7):1413-23. Epub 2004 Jun 14. [PMID: 15197164]

Massirer, K.B., M.H. Hirata, A.E. Silva, M.L. Ferraz, N.Y. Nguyen, and R.D. Hirata. Interferon-alpha receptor 1 mRNA expression in peripheral blood mononuclear cells is associated with response to interferon-alpha therapy of patients with chronic hepatitis C. Braz J Med Biol Res, 2004 May;37(5):643-7. Epub 2004 Apr 22. [PMID: 15107924]

Brentani, H. O.L. Caballero A.A. Camargo A.M. da Silva W.A. da Silva, Jr. E. Dias Neto M. Grivet A. Gruber P.E. Guimaraes W. Hide C. Iseli C.V. Jongeneel J. Kelso M.A. Nagai E.P. Ojopi E.C. Osorio E.M. Reis G.J. Riggins A.J. Simpson S. de Souza B.J. Stevenson R.L. Strausberg E.H. Tajara S. Verjovski-Almeida M.L. Acencio M.H. Bengtson F. Bettoni W.F. Bodmer M.R. Briones L.P. Camargo W. Cavenee J.M. Cerutti L.E. Coelho Andrade P.C. Costa dos Santos M.C. Ramos Costa I.T. da Silva M.R. Estecio K. Sa Ferreira F.B. Furnari M. Faria, Jr. P.A. Galante G.S. Guimaraes A.J. Holanda E.T. Kimura M.R. Leerkes X. Lu R.M. Maciel E.A. Martins K.B. Massirer A.S. Melo C.A. Mestriner E.C. Miracca L.L. Miranda F.G. Nobrega P.S. Oliveira A.C. Paquola J.R. Pandolfi M.I. Campos Pardini F. Passetti J. Quackenbush B. Schnabel M.C. Sogayar J.E. Souza S.R. Valentini A.C. Zaiats E.J. Amaral L.A. Arnaldi A.G. de Araujo S.A. de Bessa D.C. Bicknell M.E. Ribeiro de Camaro D.M. Carraro H. Carrer A.F. Carvalho C. Colin F. Costa C. Curcio I.D. Guerreiro da Silva N. Pereira da Silva M. Dellamano H. El-Dorry E.M. Espreafico A.J. Scattone Ferreira C. Ayres Ferreira M.A. Fortes A.H. Gama D. Giannella-Neto M.L. Giannella R.R. Giorgi G.H. Goldman M.H. Goldman C. Hackel P.L. Ho E.M. Kimura L.P. Kowalski J.E. Krieger L.C. Leite A. Lopes A.M. Luna A. Mackay S.K. Mari A.A. Marques W.K. Martins A. Montagnini M. Mourao Neto A.L. Nascimento A.M. Neville M.P. Nobrega M.J. O’Hare A.Y. Otsuka A.I. Ruas de Melo M.L. Paco-Larson G. Guimaraes Pereira N. Pereira da Silva J.B. Pesquero J.G. Pessoa P. Rahal C.A. Rainho V. Rodrigues S.R. Rogatto C.M. Romano J.G. Romeiro B.M. Rossi M. Rusticci R. Guerra de Sa S.C. Sant’ Anna M.L. Sarmazo T.C. Silva F.A. Soares F. Sonati Mde J. de Freitas Sousa D. Queiroz V. Valente A.L. Vettore F.E. Villanova M.A. Zago and H. Zalcberg. The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. PNAS, 2003 Nov 11;100(23):13418-23. Epub 2003 Oct 30. [PMID: 14593198]