Yeo Lab

Degrees

B.A. in Biology and Economics, University of Pennsylvania, 2010
Ph.D in Interdepartmental Biological Sciences, Northwestern University, 2016

Summary

Mark Perelis received his B.A. in Biology and Economics from the University of Pennsylvania. As an undergraduate he worked in the laboratory of Amita Sehgal where he studied metabolic pathways coupling nutrient sensing to behavior and circadian gene expression in Drosophila pacemaker neurons. Mark joined the laboratory of Joseph Bass at Northwestern University for his Ph.D. where he developed and applied mouse genetic and genomic tools to define how circadian clock proteins expressed outside of the brain regulate physiological functions. He discovered that circadian proteins expressed in pancreatic beta cells regulate the rhythmic expression of genes mediating insulin transport and secretion resulting in self-sustained rhythms in their capacity to secrete insulin. As a postdoctoral researcher in the Yeo lab Mark is interested in how RNA binding proteins respond to circadian and other environmental signaling events to modulate gene expression and metabolism.

Publications

Perelis, M., Ford, M. L. and Luo, X. Literature Watch Implications for transplantation. American Journal of Transplantation, 2015

Perelis, M, Ramsey, KM, Bass J. 2015. The molecular clock as a metabolic rheostat. Diabetes Obes Metab. 2015 Sep;17 Suppl 1:99-105.

Perelis, M§, Marcheva, B§, Ramsey, KM, Schipma, MJ, Hutchison, AL, Taguchi, A, Peek, CB, Hong, HK, Huang, W,Omura, C, Allred, AL, Bradfield, CA, Dinner, AR, Barish, GD, Bass, J. 2015. Pancreatic Beta-Cell Enhancers Regulate Rhythmic Transcription of Genes Controlling Insulin Secretion. Science. 6 November 2015. § authors contributed equally to this work.

Peek, CB, Ramsey, KM, Levine, DC, Marcheva, B, Perelis M, Bass J. 2015. Circadian regulation of cellular physiology. Methods Enzymol. Epub 2015 Jan 5.

Perelis, M, Ramsey, KM, Marcheva, B, Bass, J. 2016. Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology. Body Clocks Review Series. J Biol Rhythms. 2016 Aug.