Yeo Lab

Degrees

B.S., General Biology, University of California, San Diego, 2009
Ph.D, Biomedical Sciences, UC San Diego, 2014

Summary

Michael Lovci is a graduate student in the Biomedical Sciences program at UCSD. He received his undergraduate degree in General Biology in 2009 from UCSD. During his time as an undergraduate he was actively involved in several projects related to the analysis of high-throughput sequencing data, including RNAseq data as well as CLIP-seq data. Currently a second-year graduate student, he has developed several tools for these type of large-scale analyses. He is currently working to elucidate the role of several RNA-binding proteins and their contribution to human neurological and cardiovascular disease.

Publications

Song Y , Botvinnik OB , Lovci MT, Kakaradov B, Liu PL, Xu JL,Yeo GW. Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation. Molecular Cell 2017 July. [PDF]

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges. Lovci MT, Ghanem D, Marr H, Arnold J, Gee S, Parra M, Liang TY, Stark TJ, Gehman LT, Hoon S, Massirer KB, Pratt GA, Black DL, Gray JW, Conboy JG, Yeo GW. Nature Structural and Molecular Biology, 2013

Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans. Hunter SE, Finnegan EF, Zisoulis DG, Lovci MT, Melnik-Martinez KV, Yeo GW, Pasquinelli AE. PLoS Genetics, 2013 [PMID: 23516374]

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Wilbert MW, Huelga SC, Kapeli K, Stark TJ, Liang TY, Chen SX, Yan BY, Nathanson JL, Hutt KR, Lovci MT, Kazan H, Vu AQ, Massirer KB, Morris Q, Hoon S, Yeo GW. Molecular Cell, 2012. [Mol Cell]

RNA-seq Analysis of Gene Expression and Alternative Splicing by Double-Random Priming Stratagy. Lovci MT, Li HR, Fu XD, Yeo GW. Methods in Molecular Biology, 2011.

Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang YL, Pasquinelli AE, Yeo GW. Nature Structural and Molecular Biology, 2010. [PMID: 20062054]

L1 retrotransposition in human neural progenitor cells. Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O’Shea KS, Moran JV, Gage FH. Nature. 2009 [PMID: 19657334]

Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR. RNA. 2009 [PMID: 19553344]

Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Li H, Lovci MT, Kwon YS, Rosenfeld MG, Fu XD, Yeo GW. Proc Natl Acad Sci U S A. 2008 [PMID: 19088194]