Yeo Lab

Degrees

B.S., Biology, Neuroscience, University of Pittsburgh, 2013
M.Ed., Curriculum and Teaching, Secondary Science, University of Nevada Las Vegas, 2015

Summary

Though a San Diego native, Ruth moved across the nation to Steeler country for college, where she became fascinated by the human body, especially the study of the brain. As an undergraduate researcher in the Chu lab at the University of Pittsburgh (Pitt), she helped study the role of PINK1 in Parkinson’s disease, spending many long hours in the confocal microscope room. After graduating from Pitt, Ruth took a detour from bench science to become a high school teacher for underserved youth in Las Vegas, Nevada. Although she enjoyed making a difference in the lives of her kids (and exploring Vegas nightlife on the weekends), Ruth left the teaching life to go back to science, now working as a tech on the ENCODE team in the Yeo lab to build the world’s knowledge on the many roles of RBPs. Ruth has recently been accepted to medical school, where she hopes to continue her science training to benefit the lives of her future patients. When not pipetting, Ruth enjoys playing with her guinea pigs Callie and Phoebe, rallying for social justice, and seeking out the best flight of dark beers in San Diego.

Publications

Van Nostrand EL, Pratt GA, Yee BA, Wheeler E, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu X-D, Graveley BR, Yeo GW. Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins. Genome Biology, 2020.

Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz‑Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. Transcriptome–pathology correlation identifies interplay between TDP‑43 and the expression of its kinase CK1E in sporadic ALS. Acta Neuropathologica, 2018.

Van Nostrand EL , Nguyen TB , Gelboin-Burkhart C, Wang R, Blue SM, Pratt GA, Louie AL, Yeo GW. Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP). Methods Mol Biol. 2017 *Co-authorship.

CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins. Van Nostrand EL, Gelboin-Burkhart C, Wang R, Pratt GA, Blue SM, Yeo GW. Methods. 2016 Dec 18. pii: S1046-2023(16)30481-9. doi: 10.1016/j.ymeth.2016.12.007.

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayır H, Kagan VE. Nature Cell Biol. 2013 Oct;15(10):1197-205. doi: 10.1038/ncb2837.

Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY, Chu CT. J Neurochem. 2014 Mar;128(6):864-77. doi: 10.1111/jnc.12494.