Yeo Lab

Degrees

B.S., Computer Science with a specialization in Bioinformatics, University of California, San Diego, 2005
M.S., Biomedical Informatics and Bioinformatics, SDSU, 2013

Summary

Tiffany Yujing Liang received her B.S. in Computer Science with a specialization in Bioinformatics from UCSD in 2005. She worked closely with Gene Yeo at the Salk Institute, prior to moving to UCSD with the lab. Her work involves both computational and biological aspects of: Optimizing UV-crosslinking Immuno-precipitation (CLIP-seq); analysis of alternative splicing utilizing Affymetrix exon-array and RNA-seq data; and cell culture experiments.

Publications

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW & Yeo GW. Nature Neuroscience, 2012.

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Wilbert MW, Huelga SC, Kapeli K, Stark TJ, Liang TY, Chen SX, Yan BY, Nathanson JL, Hutt KR, Lovci MT, Kazan H, Vu AQ, Massirer KB, Morris Q, Hoon S, Yeo GW. Molecular Cell, 2012. [Mol Cell]

Integrative Genome-wide Analysis reveals cooperative regulation of Alternative Splicing by hnRNP Proteins. Huelga SC, Vu AQ, Arnold JD, Liang TY, Liu PP, Yan BY, Donohue JP, Shiue L, Hoon S, Brenner S, Ares M, Yeo GW. Cell Reports. 2012 [Open Access]

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Polymenidou M , Lagier-Tourenne C , Hutt KR , Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW , Cleveland DW ( authors contributed equally, ** co-corresponding). Nature Neuroscience, 2011. [PMID: 21358643]

Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang YL, Pasquinelli AE, Yeo GW. Nature Structural and Molecular Biology, 2010. [PMID: 20062054]

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X.D., Gage F.H.. Nature Structural & Molecular Biology 2009 [PMID: 19136955]

Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors. Yeo, G., Xu, X, Liang, T.Y., Muotri, A.R., Carson, C.T., Coufal, N.G., Gage, F.H. PLoS Computational Biology 2007 [PMID: 17967047]

Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements in mammalian genomes. Yeo, G, Van Nostrand, E, Liang, Y.T. PLoS Genetics 2007 [PMID: 17530930]