Julia Nussbacher

Graduate Student (Ph.D.)
Biomedical Sciences
jnussbac@ucsd.edu

Degrees

Sc.B Biochemistry, Brown University, 2010

Summary

Julia comes to us with experience in both academia and industry, in fields ranging from cancer diagnostics to antibiotic synthesis. As an undergraduate at Brown University, Julia completed a thesis project in the lab of Dr. Anatoly Zhitkovich. She used a lung cancer model to study the role of mismatch repair proteins in the development of chemotherapeutic resistance to DNA crosslinking compounds. Prior to joining the graduate program in biomedical sciences, Julia worked in the biotech industry in drug development and diagnostics. As a graduate student in our lab Julia is interested in the epigenetics of the transcriptome. She hopes to apply her knowledge of biochemistry and developing computational skills to understanding how RNA modifications influence neural development and neurodegeneration. When not in the lab, Julia can usually be found lifting heavy things and eating donuts.

Publications

Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M Jr, Burge CB, Taylor JP, Rigo F, Yeo GW. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016 Nov 23;92(4):780-795.

Rodvold, J. J.; Chiu, K. T.; Hiramatsu, N.; Nussbacher, J. K.; Galimberti, V.; Mahadevan, N. R.; Willert, K.; Lin, J. H.; Zanetti, M., Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal 2017, 10 (482).

Bos, T. J.; Nussbacher, J. K.; Aigner, S.; Yeo, G. W., Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins. Adv Exp Med Biol 2016, 907, 61-88.

Nussbacher, J. K.; Batra, R.; Lagier-Tourenne, C.; Yeo, G. W., RNA-binding proteins in neurodegeneration: Seq and you shall receive. Trends in neurosciences 2015.

Jakob Axelsson, Ding Xu, Bit Na Kang, Julia K. Nussbacher, Tracy M Handel, Klaus Ley, P Sriramarao, and Jeffrey D. Esko. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood blood-2012-03-417139, 2012.