Yeo Lab

Degrees

Ph.D. Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel, 2021
M.Sc. Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel, 2015
B.Sc. Life Science, Bar-Ilan University, Ramat-Gan, Israel, 2013

Summary

Orel received his B.Sc. with honor in Life-Science from the Bar-Ilan university, and upon completion, moved to the Weizmann Institute of Science for M.Sc. and PhD. program in Life-Science in the lab of Prof. Noam Stern-Ginossar at the molecular genetics department. In his thesis research, Orel focused on mapping cis-regulatory element in human and viral RNA molecules in dynamic and stationary conditions, by measuring RNA structures and signatures along viral infection. His research revealed that ribosomes are playing a major role in unwinding RNA structures in coding sequences. Moreover, he found dozens of novel cis-regulatory elements in RNA molecules that directly control RNA stability, translation and more. In 2021 Orel began his post-doctoral research with the Yeo lab, focusing on unraveling the molecular determinants along ALS progression, and exploring the role of RBPs in neurodevelopmental disorders.

Publications

Bartok O, Pataskar A, Nagel R, Laos M, Goldfarb E, Hayoun D, Levy R, Körner PR, Kreuger IZM, Champagne J, Zaal EA, Bleijerveld OB, Huang X, Kenski J, Wargo J, Brandis A, Levin Y, Mizrahi O, Alon M, Lebon S, Yang W, Nielsen MM, Stern-Ginossar N, Altelaar M, Berkers CR, Geiger T, Peeper DS, Olweus J, Samuels Y, Agami R. (2021) Anti-tumour immunity induces aberrant peptide presentation in melanoma. Nature 590: 332–337

Finkel Y, Gluck A, Nachshon A, Winkler R, Fisher T, Rozman B, Mizrahi O, Lubelsky Y, Zuckerman B, Slobodin B, Yahalom-Ronen Y, Tamir H, Ulitsky I, Israely T, Paran N, Schwartz M, Stern-Ginossar N. (2021) SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis. Nature 594:240–245

Finkel Y§, Mizrahi O§, Nachshon A, Weingarten-Gabbay S, Morgenstern D, Yahalom-Ronen Y, Tamir H, Achdout H, Stein D, Israeli O, Beth-Din A, Melamed S, Weiss S, Israely T, Paran N, Schwartz M, Stern-Ginossar N. (2021) The coding capacity of SARS-CoV-2. Nature 589:125–130
(§ co-first authorship)

Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH. (2020) Context-dependent functional compensation between Ythdf m 6 A reader proteins. Genes Dev 34: 1373-1391

Mizrahi O, Nachshon A, Shitrit A, Gelbart IA, Dobesova M, Brenner S, Kahana C, Stern-Ginossar N. (2018) Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression. Molecular cell 72:862-874

Solomon O, Di Segni A, Cesarkas K, Porath HT, Marcu-Malina V, Mizrahi O, Stern-Ginossar N, Kol N, Farage-Barhom S, Glick-Saar E, Lerenthal Y, Levanon EY, Amariglio N, Unger R, Goldstein I, Eyal E, Rechavi G. (2017) RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure. Nature communication 8

Moor AE, Golan M, Massasa EE, Lemze D, Weizman T, Shenhav R, Baydatch S, Mizrahi O, Winkler R, Golani O, Stern-Ginossar N, Itzkovitz S. (2017) Global mRNA polarization regulates translation efficiency in the intestinal epithelium. Science 357: 1299-1303