Yeo Lab

Degrees

Ph.D. Molecular and Cellular Pharmacology, Stony Brook University, 2009
M.D. Peking University, China, 2003

Summary

Yan Song came to the United States for her graduate career in 2003 after she received her MD from School of Medicine in Peking University, China. She obtained Ph.D. in Molecular and Cellular Pharmacology from Stony Brook University (aka New York State University at Stony Brook), New York in 2009 with Dr. Howard Crawford. Her graduate work focused on transcriptional network and cell signaling in tumorigenesis and cancer progression, using pancreatic cancer as the model disease. She identified two transcription factors, FOXA1 and FOXA2 as essential repressors of epithelial-to-mesenchymal transition (EMT) through their favorable regulation of E-cadherin in pancreatic cancer, suggesting that loss of FOXA1/2 signaling is a key event in inducing EMT program. In a second project, she demonstrated that a major transcription factor essential for embryonic development plays a critical role in tissue regeneration after wounding as well as tumorigenesis, using a combination of an inducible Pdx-1 knock out mouse model and a pancreatitis model. In Dr. Yeo’s lab, she is interested in understanding how RNA binding protein and RNA regulation engage in the regulatory network to direct the cell fate decision and the functionality of the cells.

Publications

Song Y , Botvinnik OB , Lovci MT, Kakaradov B, Liu PL, Xu JL,Yeo GW. Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation. Molecular Cell 2017 July. [PDF]

Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, and Ideker T. Interaction landscape of inherited polymorphisms with somatic events in cancer. Cancer Discovery. 2017.

Song Y, Washington MK, Crawford HC. Loss of FOXA1/2 is essential for epithelial-to-mesenchymal transition in pancreatic cancer. Cancer Research 2010 Mar 1;70(5):2115-25. PMID: 20160041

Song Y, Xie C, Ong YM, Gan YH, Chua KL. The BpsIR quorum-sensing system of Burkholderia pseudomallei. J Bacteriol. 2005 Jan;187(2):785-90. PMID:15629951